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The preferred formation of a CDR3 motif that constrains TCR selection by requiring conservation of the V-D recombination site would seem to limit the possibilities for convergent recombination, suggesting that selection pressure may be imposed by conformational requirements of the TCR-peptide-MHC interface

The preferred formation of a CDR3 motif that constrains TCR selection by requiring conservation of the V-D recombination site would…

The preferred formation of a CDR3 motif that constrains TCR selection by requiring conservation of the V-D recombination site would seem to limit the possibilities for convergent recombination, suggesting that selection pressure may be imposed by conformational requirements of the TCR-peptide-MHC interface Read More