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To verify that Ser-157 and Ser-161 are targeted by PKD certainly, furtherin vitrokinase assays were performed, using being a substrate either WT telethonin proteins (as above) or a mutated telethonin with substitute of the putative phospho-acceptor serine residues by non-phosphorylatable alanine, either individually or in mixture (S157A, S161A, or S157A/S161A; incomplete sequences are proven inFig

To verify that Ser-157 and Ser-161 are targeted by PKD certainly, furtherin vitrokinase assays were performed, using being a substrate…

To verify that Ser-157 and Ser-161 are targeted by PKD certainly, furtherin vitrokinase assays were performed, using being a substrate either WT telethonin proteins (as above) or a mutated telethonin with substitute of the putative phospho-acceptor serine residues by non-phosphorylatable alanine, either individually or in mixture (S157A, S161A, or S157A/S161A; incomplete sequences are proven inFig Read More