Furthermore, Itch/AIP4 has been proven to mediate polyubiquitylation-dependent targeting of retrovirally portrayed Notch1 ectodomain to lysosomes in the lack of ligand (Chastagner et al

Furthermore, Itch/AIP4 has been proven to mediate polyubiquitylation-dependent targeting of retrovirally portrayed Notch1 ectodomain to lysosomes in the lack of…